Effective action to prevent trafficking in persons requires a comprehensive approach, including measures to prevent trafficking, to protect victims of such trafficking and to prosecute traffickers. The root causes of trafficking are multifaceted. Human trafficking has grown to become such a large industry because of the seemingly unlimited supply of vulnerable victims and the high demand for sexual and labor exploitation. The “supply factors” relate to a person’s vulnerability to be trafficked. For the purposes of this notebook, organizations that deal with helping and empowering vulnerable individuals who are at a much greater risk of being exploited by others will be considered prevention agencies.